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You wake up, and your hand goes straight to your phone before your feet even touch the floor. By ten in the morning, you’re wired and foggy at the same time, reaching for sugar, caffeine, and one more scroll I already know will make me feel worse.
That pattern has a real reason behind it, and it comes down to four brain chemicals that shape how we feel every day: dopamine, oxytocin, serotonin, and endorphins. Neuroscientist TJ Power calls this system DOSE, and understanding how these four work together helps explain why your midlife energy, your focus, and that low hum of anxiety you’ve carried for years start to make sense in a whole new way.
I have been trying to get TJ Power on the show for eight months. This is my favorite episode in eight years of recording.
(02:09) — What DOSE stands for and why all four chemicals matter
(03:50) — Oxytocin, serotonin, and endorphins in plain English
(06:14) — How dopamine actually builds, and the 15-minute rule for reading
(07:31) — Golden retriever puppies and what they do to your nervous system
(08:36) — TJ’s 36 hours without a phone and what he and his wife did instead
(10:40) — Where he keeps his phone all day (it isn’t near him)
(12:35) — The 9-to-9 detox: one woman’s Saturday without a phone
(15:51) — What 50 of Alli’s clients named as their biggest time waster
(16:49) — Instagram Reels, Coca-Cola, and how much we’re really scrolling
(17:43) — Your default mode network: the wise guide you stopped listening to
(19:24) — Decision fatigue, glutamate, and the ache behind your forehead
(23:02) — Alli’s hour-long walk and the 15 minutes that are always rough
(24:08) — The 60-minute headphone-free walk that changes lives
(25:16) — Motivation is an outcome of behavior, not a prerequisite
(26:47) — Endorphins, hills, saunas, and roller coasters
(32:38) — Serotonin lives in your body, and 90% of the vagus nerve runs upward
(35:20) — Why scrolling Reels in the afternoon is chemically similar to a glass of wine
(36:32) — “Hey body, what would you like right now?” The morning practice
(38:48) — Chasing what feels good instead of escaping what feels bad
(41:12) — Do I deserve to rest? What elite athletes understand, and Alli on Sabbath
(43:11) — ADHD, dopamine, and what phones are really doing
(49:07) — “Dopamine diabetes”: the new diagnosis TJ thinks we need
(50:42) — If you only have 20 minutes a day, spend them like this
(52:36) — Whatever your first dopamine hit is, that’s what your brain craves all day
(55:29) — The phone-free first hour and how to build a life around it
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